Solid Organ Transplantation in HIV: Multi-Site Study (HIVTR)

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Coordinating Center
Emmes U.S.
Project Status
Active
Project Lifespan
09/30/2003
Objective

The project is a cooperative effort with 20 centers, sponsored by UCSF and supported by NIAID/NIH and other sources. Our multidisciplinary team of investigators and clinicians from high volume transplant centers evaluate the safety and efficacy of solid organ transplantation in people with HIV disease by conducting a prospective, multi-center cohort study of HIV-positive (+) patients who undergo kidney or liver transplantation. Our long-range goals are: 1) To provide patients and clinicians with information regarding the HIV-specific risks of transplantation, 2) To provide clinicians with information necessary to manage immunosuppression and Antiretroviral (ARV) medications together, and 3) To understand underlying basic science mechanisms that explain patient outcomes so that clinical management may be adjusted to maximize these outcomes.

Population

HIV+ subjects with renal and/or hepatic failure

Phase
Observational
Centers

University of California-SF,
Cedars-Sinai-LA,
University of Maryland,
Tulane University,
Drexel,
University of Virginia,
University of Pennsylvania,
University of Pittsburgh,
Washington Hospital Center,
Rush University,
Northwestern,
Mount Sinai School of Medicine,
Columbia University,
Georgetown Medical Center,
Beth Israel/Harvard,
University of Chicago,
University of Cincinnati,
University of Miami,
Cleveland Clinic Foundation,
Emory University,
Johns Hopkins

Products
AdvantageEDC
Services
Data Analysis and Reporting
Project Management
Regulatory Affairs
Statistical Leadership and Project Management
Study Design/Protocol Development
Training and Certification
Web-based Data Collection and Reporting Systems
Autoimmune Disease
Nephrology
Transplantation