National NeuroAIDS Tissue Consortium (NNTC)

Coordinating Center
Project Status
Project Lifespan

The National NeuroAIDS Tissue Consortium (NNTC) was established in 1998 with support from NIMH and NINDS as a multi-site data and tissue repository that collects and distributes well-characterized antemortem and postmortem tissue specimens with clinical and serological data from HIV-infected individuals.

The NNTC mission is to facilitate research on the effects of HIV infection by providing to qualified investigators high-quality, well-characterized tissue and/or data from patients with end-stage disease. Comprehensive neuromedical and neuropsychiatric data are collected antemortem and standardized postmortem protocols are followed to provide high quality tissue. Researchers can request tissues/fluids and clinical data from patients who have been characterized by:

  • degree of neurobehavioral impairment
  • neurological and other clinical diagnoses
  • history of drug use
  • antiretroviral treatments
  • blood and cerebrospinal fluid (CSF) viral load
  • neuropathological diagnosis
  • raw and summary neuropsychological test scores
  • clinical laboratory results (i.e blood chemistries, urine toxicology)
  • gene expression data

As a resource to the greater scientific community, a query tool has been released online to allow investigators to easily search the consortium's specimen holdings based on a number of clinical criteria. Please click on the following link for access: Specimen Query Tool


The NNTC targets individuals with end-stage HIV, but also collects information from HIV negative individuals who wish to donate tissues to the NNTC.

  • Texas NeuroAIDS Research Center - Galveston, TX
  • California NeuroAIDS Tissue Network - San Diego, CA
  • National Neurological AIDS Bank - Los Angeles, CA
  • Manhattan HIV Brain Bank - New York, NY
  • Statistics and Data Coordinating Center
    • The EMMES Corporation (Data Coordinating Center) - Rockville, MD
    • Indiana University School of Medicine (Statistics Coordinating Center) - Indianapolis, IN

For more information on NNTC sites, please visit the interactive Site Map.

Data Analysis and Reporting
Meeting Coordination and Support
Project Management
Statistical Leadership and Project Management
Training and Certification
Web-based Data Collection and Reporting Systems