Impact of Body Mass Index on Immunogenicity of Pandemic H1N1 Vaccine in Children and Adults

Publication Type
Journal Article
Year of Publication
2014
Authors
Callahan, ST; Wolff, M; Hill, HR; Edwards, KM; NIAID Vaccine; Treatment Evaluation Unit (VTEU) Pandemic H1N1 Vaccine Study Group
Secondary
J Infect Dis
Volume
210
Start Page
1270
Pagination
1270-1274
Date Published
10/2014
Keywords
body mass index; immune response; Influenza vaccine; obesity
ISBN
1537-6613
Abstract
Obesity emerged as a risk factor for morbidity and mortality related to 2009 pandemic influenza A (H1N1) infection. However, few studies examine the immune responses to H1N1 vaccine among children and adults of various body mass indices (BMI). Pooling data from 3 trials of unadjuvanted split-virus H1N1 A/California/07/2009 influenza vaccines, we analyzed serologic responses of participants stratified by BMI grouping. A single vaccine dose produced higher hemagglutination inhibition antibody titers at day 21 in obese compared to nonobese adults, but there were no significant differences in responses to H1N1 vaccine among children or adults of various BMI following 2 doses.
URL
http://www.ncbi.nlm.nih.gov/pubmed/24795475