Response to therapy following retreatment of serofast early syphilis patients with benzathine penicillin.
Publication Type
Journal Article
Year of Publication
2013
Authors
Seña, Arlene C; Wolff, Mark; Behets, Frieda; Van Damme, Kathleen; Martin, David H; Leone, Peter; McNeil, Linda; Hook, Edward W
Secondary
Clin Infect Dis
Volume
56
Pagination
420-2
Date Published
2013 Feb
Keywords
Adolescent; Adult; Anti-Bacterial Agents; Female; Humans; Male; Middle Aged; Penicillin G Benzathine; Retreatment; Syphilis; Syphilis Serodiagnosis; Time Factors; Treatment Outcome; Young Adult
Abstract
Persistent nontreponemal titers after treatment are common among patients with early syphilis. We retreated 82 human immunodeficiency virus-negative early syphilis participants who were serofast at 6 months using benzathine penicillin. Only 27% exhibited serological response after retreatment and after an additional 6 months of follow-up.