Factors related to long-term renal transplant function in children.

Publication Type
Journal Article
Year of Publication
Ellis, Eileen N; Martz, Karen; Talley, Lynya; Ilyas, Mohammad; Pennington, Kathy L; Blaszak, Richard T
Pediatr Nephrol
Date Published
2008 Jul
Child; Child, Preschool; Female; Graft Rejection; Graft Survival; Humans; kidney transplantation; Male; Proportional Hazards Models; Registries; Risk Assessment; Risk Factors; Time Factors; Transplantation, Homologous; Treatment Outcome

Short-term renal allograft survival in children has improved. It is therefore important to determine the factors leading to long-term graft function. To this end, we evaluated patients in the NAPTRCS registry who were <12 years old when they received their renal transplant between 1987 and 1993. Children with 10 years of post-transplant follow-up were compared to those in whom the transplant failed within 10 years. Children with a failed transplant within 10 years of the surgery tended to be older, female, and non-Caucasian; they also manifested obstructive uropathy less often and had focal segmental glomerulosclerosis more often, and they received more deceased donor kidneys. Children with a failed renal transplant had fewer HLA donor and recipient matches, received pre-transplant dialysis compared to a preemptive transplant, required dialysis in the first week post-transplant, and required more antihypertensives the first month post-transplant. Allograft function was examined at 10 years. Patients with continued allograft function and a serum creatinine