Vitamin E in the treatment of uveitis-associated macular edema.
Publication Type
Journal Article
Year of Publication
2006
Authors
Nussenblatt, Robert B; Kim, Jonghyeon; Thompson, Darby J S; Davis, Matthew D; Chew, Emily; Ferris, Frederick L; Buggage, Ronald
Secondary
Am J Ophthalmol
Volume
141
Pagination
193-4
Date Published
2006 Jan
Keywords
Adult; Aged; Child; Double-Blind Method; Female; Humans; macular edema; Male; Middle Aged; retina; Uveitis; visual acuity; Vitamin E
Abstract
PURPOSE: To investigate whether high-dose alpha-tocopherol (vitamin E) could reduce vision loss and retinal thickening associated with uveitis-associated cystoid macular edema.
DESIGN: A double-masked, randomized study.
METHODS: Uveitis patients with macular edema seen at the NIH were randomized and received either 1600 IU/day of vitamin E or placebo for 4 months. Visual acuity and retinal thickening were collected for the efficacy and the safety of the high dose of vitamin E.
RESULTS: Changes in visual acuity and retinal thickening.
CONCLUSIONS: Four-month oral supplementation with 1600 IU/d of vitamin E had no apparent effect on uveitis-associated macular edema or visual acuity in this small study.