Statistical aspects of intraperitoneal chemotherapy studies.
Year of Publication
Antineoplastic Agents; Clinical Trials as Topic; Humans; Infusions, Parenteral; Peritoneal Cavity; Random Allocation; Research Design; Statistics as Topic
When designing adjuvant studies of intraperitoneal therapy, the presumed activity of the treatment on the peritoneal surface makes control of peritoneal recurrence a possible alternative to the survival endpoint. Consideration of the potential impact of different endpoints on study sample size is presented. Disease sites for application and issues of implementation unique to studies of this type are discussed.