A case-control study of risk factors for Haemophilus influenzae type B disease in Navajo children.

Publication Type
Journal Article
Year of Publication
Wolff, M C; Moulton, L H; Newcomer, W; Reid, R; Santosham, M
Am J Trop Med Hyg
Date Published
1999 Feb
Analysis of Variance; Arizona; Asian Continental Ancestry Group; Case-Control Studies; Child; Haemophilus Infections; Haemophilus influenzae type b; Haemophilus Vaccines; Hepatitis B Vaccines; Humans; Indians, North American; Risk Factors; Rural Health; Vaccines, Conjugate; Vaccines, Synthetic

To understand the potential risk factors and protective factors for invasive Haemophilus influenzae type b (Hib) disease, we conducted a case-control study among Navajo children less than two years of age resident on the Navajo Nation. We analyzed household interview data for 60 cases that occurred between August 1988 and February 1991, and for 116 controls matched by age, gender, and geographic location. The Hib vaccine recipients were excluded from the analyses. Conditional logistic regression models were fit to examine many variables relating to social and environmental conditions. Risk factors determined to be important were never breast fed (odds ratio [OR] = 3.55, 95% confidence interval [CI] = 1.52, 8.26), shared care with more than one child less than two years of age (OR = 2.32, 95% CI = 0.91, 5.96); wood heating (OR = 2.14, 95% CI = 0.91, 5.05); rodents in the home (OR = 8.18, 95% CI = 0.83, 80.7); and any livestock near the home (OR = 2.18, 95% CI = 0.94, 5.04).