Methods and Reproducibility of Grading Optimized Digital Color Fundus Photographs in the Age-Related Eye Disease Study 2 (AREDS2 Report Number 2)

Publication Type
Journal Article
Year of Publication
2013
Authors
Danis, RP; Domalpally, A; Chew, EY; Clemons, TE; Armstrong, J; SanGiovanni, JP; Ferris, FL, 3rd; The AREDS2 Study Group
Secondary
Invest Ophthalmol Vis Sci
Volume
54
Start Page
4548
Pagination
4548-4554
Date Published
07/2013
Keywords
AMD; color photographic imaging; reproducibility
Abstract
{PURPOSE: To establish continuity with the grading procedures and outcomes from the historical data of the Age-Related Eye Disease Study (AREDS), color photographic imaging and evaluation procedures for the assessment of age-related macular degeneration (AMD) were modified for digital imaging in the AREDS2. The reproducibility of the grading of index AMD lesion components and for the AREDS severity scale was tested at the AREDS2 reading center. METHODS: Digital color stereoscopic fundus photographs from 4203 AREDS2 subjects collected at baseline and annual follow-up visits were optimized for tonal balance and graded according to a standard protocol slightly modified from AREDS. The reproducibility of digital grading of AREDS2 images was assessed by reproducibility exercises, temporal drift (regrading a subset of baseline annually
URL
http://www.ncbi.nlm.nih.gov/pubmed/23620429