Neurovirological Correlation With HIV-Associated Neurocognitive Disorders and Encephalitis in a HAART-Era Cohort

Publication Type
Journal Article
Year of Publication
2013
Authors
Gelman, B; Lisinicchia, J; Morgello, S; Masliah, E; Commins, D; Achim, C; Fox, H; Kolson, D; Grant, I; Singer, E; Yiannoutsos, C; Sherman, S; Gensler, G; Moore, D; Chen, T; Soukup, V
Secondary
J Acquir Immune Defic Syndr
Volume
62
Start Page
487
Pagination
487-495
Date Published
04/2013
Keywords
dementia; encephalitis; HAND; HIVE; interferon; neurocognitive disorders
Abstract
{OBJECTIVE:: Replicating HIV-1 in the brain is present in HIV encephalitis (HIVE) and microglial nodule encephalitis (MGNE) and is putatively linked with HIV-associated neurocognitive disorders (HAND). A clinico-neurovirological correlation was conducted to elucidate the relationship between brain viral load and clinical phenotype. SUBJECTS: and assays: HIV gag/pol RNA and DNA copies were quantified with RT-PCR or PCR in 148 HAART-era brain specimens. Comparison to HAND, HIVE and MGNE and correlation with neuropsychological (NP) test scores were done using one-way ANOVA with Tukey-Kramer and Spearman's tests respectively. RESULTS:: Brain HIV RNA was higher in subjects with HAND plus HIVE vs without HAND (delta = 2.48 log10 units
URL
http://www.ncbi.nlm.nih.gov/pubmed/23242157