Immunologic Features of Infants with Milk or Egg Allergy Enrolled in an Observational Study (Consortium of Food Allergy Research) of Food Allergy

Publication Type
Journal Article
Year of Publication
Sicherer, S; Wood, R; Stablein, D; Burks, A; Liu, A; Jones, S; Fleischer, D; Leung, D; Grishin, A; Mayer, L; Shreffler, W; Lindblad, R; Sampson, H
J Allergy Clin Immunol
Start Page
1077-1083 e1078
Date Published
allergens; Arachis hypogaea; Dermatitis; Egg Hypersensitivity; Female; Immunoglobulin E; Infant; Interleukin-4; Leukocytes; Male; Milk Hypersensitivity; Peanut Hypersensitivity; Research NIH Extramural; Risk Factors; Skin Tests
{BACKGROUND: Immune features of infants with food allergy have not been delineated. OBJECTIVES: We sought to explore the basic mechanisms responsible for food allergy and identify biomarkers, such as skin prick test (SPT) responses, food-specific IgE levels, and mononuclear cell responses, in a cohort of infants with likely milk/egg allergy at increased risk of peanut allergy. METHODS: Infants aged 3 to 15 months were enrolled with a positive SPT response to milk or egg and either a corresponding convincing clinical history of allergy to milk or egg or moderate-to-severe atopic dermatitis. Infants with known peanut allergy were excluded. RESULTS: Overall, 512 infants (67% male) were studied, with 308 (60%) having a history of a clinical reaction. Skin test responses, detectable food-specific IgE, or both revealed sensitization as follows: milk, 78%; egg, 89%; and peanut, 69%. SPT responses and food-specific IgE levels were discrepant for peanut (15% for IgE > or = 0.35 kU(A)/L and negative SPT response vs 8% for positive SPT response and IgE <0.35 kU(A)/L