MELD (The Model for End-Stage Liver Disease (MELD)) Score Is an Important Predictor of Pretransplantation Mortality in HIV-Infected Liver Transplant Candidates

Publication Type
Journal Article
Year of Publication
2010
Authors
Subramanian, A; Sulkowski, M; Barin, B; Stablein, D; Curry, M; Nissen, N; Dove, L; Roland, M; Florman, S; Blumberg, E; Stosor, V; Jayaweera, D; Huprikar, S; Fung, J; Pruett, T; Stock, P; Ragni, M
Secondary
Gastroenterology
Volume
138
Start Page
159
Pagination
159-164
Date Published
01/2010
Keywords
Adult; Cohort Studies; Female; Hepatitis C; HIV Infections; Liver Failure; liver transplantation; Male; Middle Aged; Predictive Value of Tests; Preoperative Care; Research NIH Extramural; Risk Factors; Severity of Illness Index
Abstract
{BACKGROUND & AIMS: Human immunodeficiency virus (HIV) infection accelerates liver disease progression in patients with hepatitis C virus (HCV) and could shorten survival of those awaiting liver transplants. The Model for End-Stage Liver Disease (MELD) score predicts mortality in HIV-negative transplant candidates, but its reliability has not been established in HIV-positive candidates. METHODS: We evaluated predictors of pretransplantation mortality in HIV-positive liver transplant candidates enrolled in the Solid Organ Transplantation in HIV: Multi-Site Study (HIVTR) matched 1:5 by age, sex, race, and HCV infection with HIV-negative controls from the United Network for Organ Sharing. RESULTS: Of 167 HIVTR candidates, 24 died (14.4%); this mortality rate was similar to that of controls (88/792, 11.1%
URL
http://www.ncbi.nlm.nih.gov/pubmed/19800334