Blood and Marrow Transplant Clinical Trials Network (BMT CTN): Addressing Unanswered Questions

Publication Type
Journal Article
Year of Publication
2007
Authors
Weisdorf, D; Carter, S; Confer, D; Ferrara, J; Horowitz M; Blood; Marrow Transplant Clinical Trials Network
Secondary
Biol Blood Marrow Transplant
Volume
13
Start Page
257
Pagination
257-262
Date Published
03/2007
Keywords
Bone Marrow Transplantation; Clinical Trials as Topic; Hematopoietic Stem Cell Transplantation; Multicenter Studies as Topic; National Institutes of Health (US); Prospective Studies; Research Design; Research NIH Extramural
ISBN
1083-8791
Abstract
Prospective clinical trials for blood transplantation and BMT are made more difficult by limited patient numbers, heterogeneity of clinical management strategies, and high-intensity therapy with frequent and toxic competing hazards. To address the challenges of prospective clinical study of BMT, the Blood and Marrow Transplant Clinical Trials Network (BMT CTN), sponsored by the National Heart, Lung, and Blood Institute/National Cancer Institute, was established. The network's charge is to design and execute multicenter clinical trials requiring participation from the network and from noncore centers for successful performance and to address rare diseases and unique populations that could not be well studied in individual centers. The BMT CTN organizational structure, current portfolio of studies, and scientific agenda are reviewed. Opportunities for investigators in any institution to propose trials and participate are outlined.
URL
http://www.ncbi.nlm.nih.gov/pubmed/17317578