Evaluation of Plasma Homocysteine and Risk of Age-Related Macular Degeneration
Publication Type
Journal Article
Year of Publication
2006
Authors
Seddon, J; G, Gensler; M, Klein; R, Milton
Secondary
Am J Ophthalmol
Volume
141
Start Page
201
Pagination
201-203
Date Published
01/2006
Keywords
Aged; Case-Control Studies; Cross-Sectional Studies; Female; Homocysteine; Macular Degeneration; Male; Middle Aged; Risk Factors
Abstract
PURPOSE: To assess the relationship between plasma levels of homocysteine and age-related macular degeneration (AMD). DESIGN: Cross-sectional, case-control study. METHODS: Fasting plasma homocysteine levels were measured at two centers in 934 individuals who were participating in an ancillary study of the Age-Related Eye Disease Study. There were 547 cases and 387 control subjects, who were determined by fundus photography. Conditional logistic regression analyses were conducted to assess the association of homocysteine with AMD. RESULTS: Median values of homocysteine were higher among advanced AMD cases (9.51 mmol/l) compared with persons with no AMD (8.81 mmol/l; P = .01). Values of >12 mmol/l vs < or =12 mmol/l were also associated with an increased risk of AMD (P = .023), when controlled for other covariates. CONCLUSION: Results are consistent with a possible small, independent association between higher homocysteine levels and AMD. Homocysteine may be a modifiable risk factor for AMD.
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