Ocular surface indicators and biomarkers in chronic ocular graft-versus-host disease: a prospective cohort study.
2021 Mar 08
Journal Article
Authors:
Pietraszkiewicz, A.A.;
Payne, D.;
Abraham, M.;
Garced, A.;
Devarasetty, K.C.;
Wall, M.;
Menezes, S.M.;
Ugarte, S.;
Pirsl, F.;
Goklemez, S.;
Ferris, F.L.;
Barrett, J.;
Battiwalla, M.;
Childs, R.W.;
Pavletic, S.Z.;
Bishop, R.J.
Secondary:
Bone Marrow Transplant
PMID:
33686249
URL:
https://pubmed.ncbi.nlm.nih.gov/33686249/
DOI:
10.1038/s41409-021-01254-5
Keywords:
allogeneic hematopoietic stem cell transplant (HSCT); longitudinal cohort study; ocular graft-versus-host disease (oGVHD)
Abstract:
This longitudinal cohort study compared ocular surface indicators in forty allogeneic hematopoietic stem cell transplant (HSCT) subjects with twenty healthy controls at baseline and identified changes in ocular graft-versus-host disease (oGVHD). Outcome measures included: Ocular Surface Disease Index (OSDI), tear osmolarity, Schirmer's test, Oxford corneal staining score, tear break-up time (TBUT), and tear and serum biomarkers (IFN-γ, IL-10, MMP-9, IL-12, IL-13, IL-17α, IL-1β, IL-2, IL-4, IL-6, IL-8, CXCL10, MCP-1, MIP-1α, RANTES, TNF-α). At baseline the HSCT group had higher median Oxford corneal staining score (1.7 vs. 0.0; P < 0.0001), higher tear TNF-α (20.0 vs. 11.2 pg/mL; P < 0.0001), lower tear RANTES (70.4 vs. 190.2 pg/mL; P < 0.0001), higher serum IL-8 (10.2 vs. 4.5 pg/mL; P = 0.0008), and higher serum TNF-α (8.7 vs. 4.2 pg/mL; P < 0.0001). The incidence of oGVHD was 62% and associated changes included increased Oxford corneal staining score (4.6 vs. 1.8, P = 0.0001), decreased Schirmer's test (3.0 vs. 10.0; P < 0.0001), and decreased TBUT (4.7 vs. 9.0 s; P = 0.0004). Baseline differences in ocular surface indicators suggest a tendency toward ocular dryness in individuals with hematologic disorders preparing for HSCT. Individuals who developed oGVHD showed changes in corneal staining score, Schirmer's test, and TBUT.
