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National Institute of Neurological Disorders and Stroke Common Data Elements: Public Review and Updates to the Stroke Recommendations.


Gay, K.; Collie, D.; Sheikh, M.; Esterlitz, J.; Saver, J.; Warach, S.; Wright, C.B.; Mendoza-Puccini, C.; Janis, Son behalf


Common Data Element (CDE); NINDS; Public Review and Updates; Stroke Recommendations

National Institute of Neurological Disorders and Stroke Common Data Elements: Public Review and Updates to the Stroke Recommendations Authors: Katelyn Gay, BS1; Damon Collie, MSHS1; Muniza Sheikh, MS, MBA1; Joy Esterlitz, MS1; Jeffrey Saver, MD, FAHA, FAAN2; Steven Warach, MD, PhD3; Clinton B. Wright, MD, MS, FAAN4; M. Carolina Mendoza-Puccini, MD4; Scott Janis, PhD4 on behalf of the Stroke V2.0 CDE Working Group 1The Emmes Company, Rockville, MD; 2Ronald Reagan UCLA Medical Center, Los Angeles, CA; 3University of Texas, Austin, TX; 4The National Institute of Neurological Disorders and Stroke, Bethesda, MD Objective: The National Institute of Neurological Disorders and Stroke (NINDS) initiated the Common Data Element (CDE) project to provide standardized clinical research data collection formats that increase the efficiency and effectiveness of studies and reduce start-up time, as well as improve data quality and facilitate and accelerate data sharing. In 2010, Stroke-specific CDEs were posted on the NINDS CDE website. The Stroke Oversight Committee (OC) reviewed Core CDEs in 2015; and in 2018, recommended that Stroke CDEs undergo a comprehensive review and update to Version 2.0. Background: In August 2018, a Stroke V2.0 Working Group (WG) consisting of over 50 worldwide subject matter experts was convened by NINDS. The WG was asked to review all current Stroke CDEs and subarachnoid hemorrhage and unruptured cerebral aneurysms (SAH) CDEs (developed in 2017) for harmonization and inclusion within Stroke V2.0. Methods: The Stroke V2.0 WG divided into eight domain-specific subgroups: Biospecimens, Biomarkers, and Laboratory Tests; Hospital Course and Acute Therapies; Imaging; Long Term Therapies; Medical History and Prior Health Status; Outcomes and Endpoints; Stroke Presentation and Vital Signs; and Stroke Types and Subtypes. Subgroups met regularly to review, revise and add to the existing Stroke CDEs based on developments in stroke research. Following an internal WG review, a public review of the draft updates will be held. The WG will consider public feedback before V2.0 is finalized. The Stroke OC plans to review the project status at the 2020 International Stroke Conference. Results: The Stroke V2.0 CDE recommendations will include updated and new template case report forms, data dictionaries, instrument informational documents and guideline documents. The updates will reflect the current state of science, streamline CDE recommendations, and incorporate SAH CDEs. Stroke V2.0 CDEs will be available on the NINDS CDE website in 2020. Conclusions: The NINDS CDEs are periodically revised as research progresses. Through the update of the Stroke CDEs to V2.0, the initiative strives to maintain the utility of CDEs as a valuable clinical research resource. NINDS encourages use of CDEs to standardize research data collection across studies.

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