Combination chemotherapy for locally advanced pancreatic cancer: equivalence to external beam irradiation and implication for future management.
1983 Jul
Journal Article
Authors:
Smith, F.P.;
Stablein, D.;
Korsmeyer, S.;
Neefe, J.;
Chun, B.K.;
Woolley, P.V.;
Schein, P.S.
Secondary:
J Clin Oncol
Volume:
1
Pagination:
413-5
Issue:
7
PMID:
6689426
Keywords:
Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Doxorubicin; Female; Fluorouracil; Humans; Male; Middle Aged; Mitomycin; Mitomycins; Pancreatic Neoplasms; Radiotherapy Dosage
Abstract:
Chemotherapy with 5-fluorouracil, doxorubicin, and mitomycin-C was administered to 17 patients with locally advanced pancreatic cancer. The median survival for these patients was 8 months. With a multiaxial retrospective analysis, the overall survival of this study group appears to be least equivalent to that reported with 6,000 photon rad alone or of neutrons, and compares favorably to that achieved with combined 6,000 photo rad plus 5-fluorouracil. Of 15 relapses, only 4 had presented with evidence of disseminated disease. Based upon this analysis we recommend additional studies of combination chemotherapy with radiation therapy in future prospective randomized trials.
