Applicability of NINDS-sponsored studies to community-based physician involvement.
2008 May 06
Journal Article
Authors:
Lindblad, A.S.;
Clemons, T.;
Lindblad, R.W.;
Sykes, R.;
Meador, K.J.;
Odenkirchen, J.C.;
Hart, R.G.
Secondary:
Neurology
Volume:
70
Pagination:
1688-90
Issue:
19
PMID:
18057316
DOI:
10.1212/01.wnl.0000284608.57974.ba
Keywords:
Biomedical Research; Clinical Trials as Topic; Community Health Centers; Humans; Interdisciplinary Communication; Mass Screening; National Institutes of Health (U.S.); neurology; Patient Selection; physicians; Research Support as Topic; United States
Abstract:
BACKGROUND: The National Institute of Neurological Disorders and Stroke (NINDS) Clinical Trials Group established the Clinical Research Collaboration (CRC) Project in 2005 to increase community-based physician involvement in NINDS-sponsored research.METHODS: We assessed a random sample of 112 of the more than 1,000 current NINDS-sponsored clinical research studies to determine which could involve community physicians in enrollment or follow-up. Scoring factors were based on the premise that participation is feasible for noninvasive studies with simple screening, and follow-up criteria and visit frequency consistent with usual care. Scored studies included 26 Phase III, 31 Phase I/II, and 55 nonclinical trials.RESULTS: Overall, 41% of the sampled research studies were considered conducive to community physician participation that exceeds referral only; 21% with participation in all study activities and 20% with ability to provide some follow-up. Specialized neuropsychological or neurologic scale testing was judged to exclude community physician participation in 16% of studies.CONCLUSION: Many National Institute of Neurological Disorders and Stroke studies are available in which community-based physicians could participate. Involving community physicians may increase efficiency of completing clinical research and encourage application of research findings in community practices.
