Impact of antioxidants, zinc, and copper on cognition in the elderly: a randomized, controlled trial.
2004 Nov 09
Journal Article
Authors:
Yaffe, K.;
Clemons, T.E.;
McBee, W.L.;
Lindblad, A.S.
Secondary:
Neurology
Volume:
63
Pagination:
1705-7
Issue:
9
PMID:
15534261
DOI:
10.1212/01.wnl.0000142969.19465.8f
Keywords:
Aged; Antioxidants; Ascorbic Acid; Beta Carotene; Cognition Disorders; Copper; Female; Humans; Male; Middle Aged; Vitamin E; Zinc
Abstract:
Participants in the Age-Related Eye Disease Study were randomly assigned to receive daily antioxidants (vitamin C, 500 mg; vitamin E, 400 IU; beta carotene, 15 mg), zinc and copper (zinc, 80 mg; cupric oxide, 2 mg), antioxidants plus zinc and copper, or placebo. A cognitive battery was administered to 2,166 elderly persons after a median of 6.9 years of treatment. Treatment groups did not differ on any of the six cognitive tests (p > 0.05 for all). These results do not support a beneficial or harmful effect of antioxidants or zinc and copper on cognition in older adults.
