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Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular degeneration.

2010 Dec

Journal Article

Kopplin, L.J.; Igo, R.P.; Wang, Y.; Sivakumaran, T.A.; Hagstrom, S.A.; Peachey, N.S.; Francis, P.J.; Klein, M.L.; SanGiovanni, J.P.; Chew, E.Y.; Pauer, G.J.T.; Sturgill, G.M.; Joshi, T.; Tian, L.; Xi, Q.; Henning, A.K.; Lee, K.E.; Klein, R.; Klein, B.E.K.; Iyengar, S.K.

Genes Immun






Adult; Aged; Aged, 80 and over; Alleles; Complement Factor H; DNA Helicases; Genome-Wide Association Study; Genotype; Humans; Macular Degeneration; Middle Aged; Polymorphism, Single Nucleotide; Proteins; Vesicular Transport Proteins

Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly in the developed world. We conducted a genome-wide association study in a series of families enriched for AMD and completed a meta-analysis of this new data with results from reanalysis of an existing study of a late-stage case-control cohort. We tested the top findings for replication in 1896 cases and 1866 controls and identified two novel genetic protective factors for AMD. In addition to the complement factor H (CFH) (P=2.3 × 10⁻⁶⁴) and age-related maculopathy susceptibility 2 (ARMS2) (P=1.2 × 10⁻⁶⁰) loci, we observed a protective effect at rs429608, an intronic SNP in SKIV2L (P=5.3 × 10⁻¹⁵), a gene near the complement component 2 (C2)/complement factor B (BF) locus, that indicates the protective effect may be mediated by variants other than the C2/BF variants previously studied. Haplotype analysis at this locus identified three protective haplotypes defined by the rs429608 protective allele. We also identified a new potentially protective effect at rs2679798 in MYRIP (P=2.9 × 10⁻⁴), a gene involved in retinal pigment epithelium melanosome trafficking. Interestingly, MYRIP was initially identified in the family-based scan and was confirmed in the case-control set. From these efforts, we report the identification of two novel protective factors for AMD and confirm the previously known associations at CFH, ARMS2 and C3.

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