Multimodal imaging in type 2 idiopathic macular telangiectasia.
2015 Apr
Journal Article
Authors:
Sallo, F.B.;
Leung, I.;
Clemons, T.E.;
Peto, T.;
Bird, A.C.;
Pauleikhoff, D.
Secondary:
Retina
Volume:
35
Pagination:
742-9
Issue:
4
PMID:
25412037
DOI:
10.1097/IAE.0000000000000365
Keywords:
Adult; Aged; Aged, 80 and over; Female; Fluorescein Angiography; Humans; Male; Middle Aged; Multimodal Imaging; Optical Imaging; Phenotype; Prospective Studies; Retinal Telangiectasis; Retinal Vessels; Tomography, Optical Coherence
Abstract:
BACKGROUND: Macular telangiectasia Type 2 is a bilateral, progressive potentially blinding retinal disease characterized by both vascular and neurodegenerative signs that have been documented using different imaging techniques. The correlation between macular telangiectasia Type 2 signs from various imaging modalities is unknown. Our aim was to investigate the relationship of various macular telangiectasia Type 2 signs using fundus fluorescein angiography, optical coherence tomography and dual-wavelength autofluorescence images.METHODS: Participants were selected from the macular telangiectasia Type 2 Natural History Observation Study, based on a confirmed diagnosis and the availability of images. Signs in fundus fluorescein angiography, dual-wavelength autofluorescence, and optical coherence tomography images were graded according to standardized categories, and agreement among the multimodel imaging was assessed statistically.RESULTS: One hundred and ninety-one eyes of 96 patients were examined. Significant correlations were found between early and late fundus fluorescein angiography (ρ = 0.82, P < 0.0001), luteal pigment loss and early/late fundus fluorescein angiography signs (ρ = 0.52, P < 0.0001 and ρ = 0.62, P < 0.0001, respectively), inner and outer segment break length and pigment loss (Class 1 vs. 2/3, P < 0.0001; Class 2 vs. 3, P = 0.04). Correlation between pigment loss and retinal spaces/atrophic retinal restructuring was fair (κ = 0.25-0.33). Bilateral symmetry was slight to substantial (κ = 0.18-0.62).CONCLUSION: Our data demonstrate the relative extent of neurodegenerative and vascular signs; it may be useful for designing systems for staging disease severity using multimodal imaging and may also provide clues to the pathogenesis of the disease.
