A comparison between recipients receiving matched kidney and those receiving mismatched kidney from the same cadaver donor
04/2002
Journal Article
Authors:
Bresnahan, B.;
Johnson, C.;
McIntosh, M.;
Stablein, D.;
Hariharan, S.
Secondary:
Am J Transplant
Volume:
2
Pagination:
366-372
URL:
http://www.ncbi.nlm.nih.gov/pubmed/12118860
Keywords:
Adolescent; Adult; Cadaver; Graft Rejection/Survival; Histocompatibility; HLA Antigens; kidney transplantation; Middle Aged; Organ Preservation; Proportional Hazards Models; Temperature; Time Factors; Tissue Donors; Transplantation-Homologous; Travel
Abstract:
{The optimal allocation of cadaveric kidneys for transplantation with reference to human leukocyte antigen (HLA) match and sharing these organs to a distant center remains controversial. The current analysis was performed using the United Network for Organ Sharing (UNOS) database for cadaveric kidney transplants (Tx) between 1988 and 1997. The graft survivals of zero-mismatch (matched) kidneys with the mate (mismatched) kidneys were compared. There were 2385 donors and 4770 Tx. Significant differences in recipient demographics between matched and mismatched Tx were: fewer African-American race (AA) in the matched group (9.0% vs. 21.9%), higher number of previous Tx (25.5% vs. 14.8%) and elevated mean cold ischemia time (24.0 vs. 22.2 h). Post-Tx dialysis requirements were similar (22.8% vs. 24.1%
