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The Influence of Immunomodulatory Diets on Transplant Success and Complications


Journal Article

Alexander, J.W.; Metze, T.J.; McIntosh, M.J.; Goodman, H.R.; First, M.R.; Munda, R.; Cardi, M.A.; Austin, J.N.; Goel, S.; Safdar, S.; Greenberg, N.; Chen, X.; Woodle, E.S.





Body Weight; Calcineurin; Dietary Supplements; Female; Graft Rejection; Graft Survival; Immunosuppression; Immunosuppressive Agents; kidney transplantation; Lipids; Male; Middle Aged; Nitric Oxide

{BACKGROUND: Animal studies have shown that dietary supplementation with arginine and lipids containing the omega-3 and omega-9 fatty acids prolong allograft survival in animals receiving a short course of low-dose cyclosporine. They also reduce cardiovascular complications and infections in humans. METHODS: Adult renal transplant patients receiving standard immunosuppression were stratified according to gender, diabetic state, donor source (LD or CD), and first versus repeat transplant, and randomized to receive or not receive supplemental arginine and canola oil (containing both omega-3 and omega-9 fatty acids) twice daily. Patients were followed for a minimum of 3 years. RESULTS: Seventy-six patients were randomized to the supplement group (S) and 71 patients to the control group (C). Intent-to-treat analysis revealed that S patients had fewer post-30 day first rejection episodes (5.4%) when compared with the C group (23.7%) (P=0.01) and fewer post-30 day episodes of calcineurin inhibitor (CNI) drug toxicity (9.2% vs. 35.3%

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