Randomized Cinical Trial of Vitamin E in the Treatment of Uveitis-Associated Macular Edema
01/2006
Journal Article
Authors:
Nussenblatt, R.B.;
Kim, J.;
Thompson, D.J.S.;
Davis, M.D.;
Chew, E.;
Ferris, F.L.;
Buggage, R.R.
Secondary:
Am J Ophthalmol
Volume:
141
Pagination:
193-194
URL:
http://www.ncbi.nlm.nih.gov/pubmed/16386999
Keywords:
Adult; Aged; Child; Double-Blind Method; Female; macular edema; Male; Middle Aged; retina; Uveitis; visual acuity; Vitamin E
Abstract:
PURPOSE: To investigate whether high-dose alpha-tocopherol (vitamin E) could reduce vision loss and retinal thickening associated with uveitis-associated cystoid macular edema. DESIGN: A double-masked, randomized study. METHODS: Uveitis patients with macular edema seen at the NIH were randomized and received either 1600 IU/day of vitamin E or placebo for 4 months. Visual acuity and retinal thickening were collected for the efficacy and the safety of the high dose of vitamin E. RESULTS: Changes in visual acuity and retinal thickening. CONCLUSIONS: Four-month oral supplementation with 1600 IU/d of vitamin E had no apparent effect on uveitis-associated macular edema or visual acuity in this small study.
