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Antigen-Specific T-Lymphocyte Function After Cord Blood Transplantation


Journal Article

Cohen, G.; Carter, S.; Weinberg, K.; Masinsin, B.; Guinan, E.; Kurtzberg, J.; Wagner, J.; Kernan, N.; Parkman, R.

Biol Blood Marrow Transplant




Adolescent; Antibodies- Viral; Cell Lineage; Child; Clinical trials; Cord Blood Stem Cell Transplantation; Cytomegalovirus; False Negative Reactions; Female; Fetal Blood; Graft vs Host Disease; Herpes Simplex / Zoster; Herpesvirus 3- Human; Infant

It has not been possible to determine the singular contribution of naive T lymphocytes to antigen-specific immunity after hematopoietic stem cell transplantation (HSCT), because of the confounding effects of donor-derived antigen-specific T lymphocytes present in most hematopoietic stem cell (HSC) products. Because umbilical cord blood contains only naive T lymphocytes, we longitudinally evaluated the recipients of unrelated cord blood transplantation (UCBT) for the presence of T lymphocytes with specificity for herpesviruses, to determine the contribution of the naive T lymphocytes to antigen-specific immune reconstitution after HSCT. Antigen-specific T lymphocytes were detected early after UCBT (herpes simplex virus on day 29; cytomegalovirus on day 44; varicella zoster virus on day 94). Overall, 66 of 153 UCBT recipients developed antigen-specific T lymphocytes to 1 or more herpesviruses during the evaluation period. The likelihood of developing antigen-specific T lymphocyte function was not associated with immunophenotypic T lymphocyte reconstitution, transplant cell dose, primary disease, or acute and chronic graft-versus-host disease. These results indicate that naive T lymphocytes present in the HSC inoculum can contribute to the generation of antigen-specific T-lymphocyte immunity early after transplantation.

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