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Centrum Use and Progression of Age-Related Cataract in the Age-Related Eye Disease Study (AREDS): A Propensity Score Approach. AREDS Report No. 21


Journal Article

Milton, R.; Sperduto, R.; Clemons, T.; , ; AREDS), A.R.Eye Diseas





Aged; aging; cataract; Cohort Studies; Disease Progression; Drug Combinations; Female; Lens-Crystalline; Logistic Models; Male; Photography; Prospective Studies; Treatment Outcome; Vitamins

{PURPOSE: To evaluate the effect of the multivitamin Centrum on the development and progression of age-related lens opacities. DESIGN: Clinic-based prospective cohort study. PARTICIPANTS: Four thousand five hundred ninety individuals with at least one natural lens and photographic follow-up (median, 6.3 years) were assessed for development or progression of lens opacities. MAIN OUTCOME MEASURES: Progression of "any" lens opacity or type-specific opacity was ascertained from lens photographs taken at baseline and at annual visits beginning at year 2. METHODS: The Age-Related Eye Disease Study (AREDS) showed no statistically significant effect of a high-dose antioxidant formulation on progression of lens opacities. Centrum also was provided to approximately two thirds of the study participants. Because Centrum use was elective, a logistic regression model of baseline characteristics was used to generate a propensity score for Centrum use. Repeated-measures logistic regression, adjusted for propensity score and other covariates, was used to evaluate associations of Centrum use and lens opacity. RESULTS: Centrum use, adjusted for propensity score and other covariates, was associated with a reduction in "any" lens opacity progression (odds ratio [OR] = 0.84, 95% confidence interval [CI] = 0.72-0.98

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