Factors Related to Long-Term Renal Transplant Function in Children
07/2008
Journal Article
Authors:
Ellis, E.N.;
Martz, K.;
Talley, L.;
Ilyas, M.;
Pennington, K.L.;
Blaszak, R.T.
Secondary:
Pediatr Nephrol
Volume:
23
Pagination:
1149-1155
URL:
http://www.ncbi.nlm.nih.gov/pubmed/18301925
Keywords:
Child; Female; Germany; Graft Rejection; Graft Survival; Homologous; kidney transplantation; Male; Pediatric nephrology; Preschool; Proportional Hazards Models; Registries; Risk Assessment; Risk Factors; Time Factors; Transplantation; Treatment Outcome
Abstract:
Short-term renal allograft survival in children has improved. It is therefore important to determine the factors leading to long-term graft function. To this end, we evaluated patients in the NAPTRCS registry who were <12 years old when they received their renal transplant between 1987 and 1993. Children with 10 years of post-transplant follow-up were compared to those in whom the transplant failed within 10 years. Children with a failed transplant within 10 years of the surgery tended to be older, female, and non-Caucasian; they also manifested obstructive uropathy less often and had focal segmental glomerulosclerosis more often, and they received more deceased donor kidneys. Children with a failed renal transplant had fewer HLA donor and recipient matches, received pre-transplant dialysis compared to a preemptive transplant, required dialysis in the first week post-transplant, and required more antihypertensives the first month post-transplant. Allograft function was examined at 10 years. Patients with continued allograft function and a serum creatinine
