Recombinant Growth Hormone Use Pretransplant and Risk for Post-Transplant Lymphoproliferative Disease–a Report of the NAPRTCS
09/2008
Journal Article
Authors:
Dharnidharka, V.R.;
Talley, L.;
Martz, K.;
Stablein, D.;
Fine, R.
Secondary:
Pediatr Transplant
Volume:
12
Pagination:
689-695
URL:
http://www.ncbi.nlm.nih.gov/pubmed/18179637
Keywords:
Adolescent; Child; Cohort Studies; Growth Hormone; Immunosuppressive Agents; Infant; kidney transplantation; Lymphoproliferative Disorders; Registries; Retrospective Studies; Risk; Transplantation Conditioning; Treatment Outcome
Abstract:
{rhGH, widely used to optimize linear growth in children with ESRD, also modulates B-cell precursor development and may be associated with malignancy development. To determine if rhGH use in children was associated with higher risk of PTLD, we analyzed retrospectively collected data on children with CRI, on dialysis or with renal transplants in a large multi-center registry of children with ESRD. Of the 194 LPD patients currently listed in the registry, 41 were previously enrolled in the CRI registry and 18/41 (43.9%) used rhGH during their period with CRI. Among CRI patients who later received a transplant, rates of PTLD post-transplant were significantly higher among rhGH users (18/407 or 4.4%) compared to patients who never used rhGH during their CRI follow-up and received a transplant (23/1240 or 1.9%
