MELD (The Model for End-Stage Liver Disease (MELD)) Score Is an Important Predictor of Pretransplantation Mortality in HIV-Infected Liver Transplant Candidates
01/2010
Journal Article
Authors:
Subramanian, A.;
Sulkowski, M.;
Barin, B.;
Stablein, D.;
Curry, M.;
Nissen, N.;
Dove, L.;
Roland, M.;
Florman, S.;
Blumberg, E.;
Stosor, V.;
Jayaweera, D.;
Huprikar, S.;
Fung, J.;
Pruett, T.;
Stock, P.;
Ragni, M.
Secondary:
Gastroenterology
Volume:
138
Pagination:
159-164
URL:
http://www.ncbi.nlm.nih.gov/pubmed/19800334
Keywords:
Adult; Cohort Studies; Female; Hepatitis C; HIV Infections; Liver Failure; liver transplantation; Male; Middle Aged; Predictive Value of Tests; Preoperative Care; Research NIH Extramural; Risk Factors; Severity of Illness Index
Abstract:
{BACKGROUND & AIMS: Human immunodeficiency virus (HIV) infection accelerates liver disease progression in patients with hepatitis C virus (HCV) and could shorten survival of those awaiting liver transplants. The Model for End-Stage Liver Disease (MELD) score predicts mortality in HIV-negative transplant candidates, but its reliability has not been established in HIV-positive candidates. METHODS: We evaluated predictors of pretransplantation mortality in HIV-positive liver transplant candidates enrolled in the Solid Organ Transplantation in HIV: Multi-Site Study (HIVTR) matched 1:5 by age, sex, race, and HCV infection with HIV-negative controls from the United Network for Organ Sharing. RESULTS: Of 167 HIVTR candidates, 24 died (14.4%); this mortality rate was similar to that of controls (88/792, 11.1%
