A Phase III Equivalence Trial of Azithromycin vs. Benzathine Penicillin for Treatment of Early Syphilis
06/2010
Journal Article
Authors:
Hook, E.;
Behets, F.;
Van Damme, K.;
Ravelomanana, N.;
Leone, P.;
Seña, A.;
Martin, D.;
Langley, C.;
McNeil, L.;
Wolff, M.
Secondary:
J Infect Dis
Volume:
201
Pagination:
1729-1735
URL:
http://www.ncbi.nlm.nih.gov/pubmed/20402591
Keywords:
Adolescent; Adult; Anti-Bacterial Agents; Azithromycin; Female; Male; Middle Aged; Penicillin G Benzathine; Research NIH Extramural; Research U.S. Gov Non-PHS; Syphilis; Treatment Outcome
Abstract:
BACKGROUND: Syphilis remains an important source of morbidity worldwide. Long-acting penicillin is the only therapy currently recommended for syphilis in much of the world. Because of hesitation to use penicillin for fear of anaphylaxis, there is a need for an effective, well-tolerated alternative to penicillin for syphilis therapy. METHODS: This multicenter, randomized clinical trial was conducted in clinics for the treatment of persons with sexually transmitted diseases. We compared serological cure rates for human immunodeficiency virus (HIV)-negative persons with early syphilis treated with azithromycin at a dosage of 2.0 g administered orally as a single dose with cure rates for those treated with benzathine penicillin G at a dosage of 2.4 million units administered intramuscularly. RESULTS: A total of 517 participants were enrolled in the trial. In the intention-to-treat analysis, after 6 months of follow-up, serological cure was observed in 180 (77.6%) of 232 azithromycin recipients and 186 (78.5%) of 237 penicillin recipients (1-sided lower bound 95% confidence interval, 7.2%). Nonserious adverse events were more common among azithromycin recipients than they were among penicillin recipients (61.5% vs 46.3%), and such adverse events were accounted for, in large part, by self-limited gastrointestinal complaints. CONCLUSIONS: In this trial, the efficacy of azithromycin at a dosage of 2.0 g administered orally was equivalent to that of benzathine penicillin G for the treatment of early syphilis in persons without HIV infection.
