Cognitive and Academic Outcomes after Pediatric Liver Transplantation: Functional Outcomes Group (FOG) Results
02/2011
Journal Article
Authors:
Sorensen, L.;
Neighbors, K.;
Martz, K.;
Zelko, F.;
Bucuvalas, J.;
Alonso, E.
Secondary:
Am J Transplant
Volume:
11
Pagination:
303-311
URL:
http://www.ncbi.nlm.nih.gov/pubmed/21272236
Keywords:
Child; Cognition; Cognition Disorders; Cohort Studies; Educational Status; Executive Function; Female; Humans; Intelligence Tests; Learning Disorders; liver transplantation; Longitudinal Studies; Male; Preschool; Research Support NIH Extramural
Abstract:
This multicenter study examined prevalence of cognitive and academic delays in children following liver transplant (LT). One hundred and forty-four patients ages 5-7 and 2 years post-LT were recruited through the SPLIT consortium and administered the Wechsler Preschool and Primary Scale of Intelligence, 3rd Edition (WPPSI-III), the Bracken Basic Concept Scale, Revised (BBCS-R), and the Wide Range Achievement Test, 4th edition (WRAT-4). Parents and teachers completed the Behavior Rating Inventory of Executive Function (BRIEF). Participants performed significantly below test norms on intelligence quotient (IQ) and achievement measures (Mean WPPSI-III Full Scale IQ = 94.7 +/- 13.5; WRAT-4 Reading = 92.7 +/- 17.2; WRAT-4 Math = 93.1 +/- 15.4; p < 0001). Twenty-six percent of patients (14% expected) had 'mild to moderate' IQ delays (Full Scale IQ = 71-85) and 4% (2% expected) had 'serious' delays (Full Scale IQ
