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Associations Between Genetic Polymorphisms of Insulin-Like Growth Factor Axis Genes and Risk for Age-Related Macular Degeneration


Journal Article

CJ, C.; YP, C.; MB, G.; G, G.; CQ, L.; F, S.; A, T.

Invest Ophthalmol Vis Sci




Aged; Case-Control Studies; Diet; Female; Genotype; Glycemic Index; Humans; Macular Degeneration/genetics; Male; Middle Aged; Polymorphism-Single Nucleotide; Receptor IGF Type 1/geneticsm Risk Factors; Somatomedins/genetics

{PURPOSE: To investigate whether insulin-like growth factor (IGF) axis genes, together with a novel dietary risk factor, the dietary glycemic index (dGI), and body mass index (BMI) affect the risk for age-related macular degeneration (AMD). METHODS: This case-control study involved 962 subjects originally recruited through the Age-Related Eye Disease Study (AREDS) Genetic Repository. After those with missing covariates or invalid calorie intake (n = 23), diabetes (n = 59), and non-Caucasian race (n = 16) were excluded, 864 participants were used, including 209 AREDS category 1 participants (control group), 354 category 2 or 3 participants (drusen group), and 301 category 4 participants (advanced AMD group). A total of 25 single-nucleotide polymorphisms (SNPs) selected from IGF-1 (n = 9), IGF-2 (n = 1), IGF binding protein 1 (IGFBP1; n = 3), IGFBP3 (n = 3), acid-labile subunit of IGFBP (IGFALS; n = 2), IGF1 receptor (IGF1R; n = 4), and IGF2R (n = 3) were genotyped. SNP-AMD associations were measured with genotype, allele χ(2) tests and Armitage's trend test. Odds ratios (OR), 95% confidence intervals (CIs), and SNP-exposure interactions were evaluated by multivariate logistic regression. RESULTS: One SNP (rs2872060) in IGF1R revealed a significant association with advanced AMD (P-allele = 0.0009

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