Methods and Reproducibility of Grading Optimized Digital Color Fundus Photographs in the Age-Related Eye Disease Study 2 (AREDS2 Report Number 2)
07/2013
Journal Article
Authors:
Danis, R.P.;
Domalpally, A.;
Chew, E.Y.;
Clemons, T.E.;
Armstrong, J.;
SanGiovanni, J.P.;
, ;
Group, T.A.R.E.D.S.2 Stu
Secondary:
Invest Ophthalmol Vis Sci
Volume:
54
Pagination:
4548-4554
URL:
http://www.ncbi.nlm.nih.gov/pubmed/23620429
Keywords:
AMD; color photographic imaging; reproducibility
Abstract:
{PURPOSE: To establish continuity with the grading procedures and outcomes from the historical data of the Age-Related Eye Disease Study (AREDS), color photographic imaging and evaluation procedures for the assessment of age-related macular degeneration (AMD) were modified for digital imaging in the AREDS2. The reproducibility of the grading of index AMD lesion components and for the AREDS severity scale was tested at the AREDS2 reading center. METHODS: Digital color stereoscopic fundus photographs from 4203 AREDS2 subjects collected at baseline and annual follow-up visits were optimized for tonal balance and graded according to a standard protocol slightly modified from AREDS. The reproducibility of digital grading of AREDS2 images was assessed by reproducibility exercises, temporal drift (regrading a subset of baseline annually
