Evaluation of Optimized Digital Fundus Reflex Photographs for Lens Opacities in the Age-Related Eye Disease Study 2: AREDS2 Report 7
09/2013
Journal Article
Authors:
Domalpally, A.;
Danis, R.P.;
Chew, E.Y.;
Clemons, T.E.;
Reed, S.;
SanGiovanni, J.P.;
, ;
Group, T.AgeRelate
Secondary:
Invest Ophthalmol Vis Sci
Volume:
54
Pagination:
5989-5994
URL:
http://www.ncbi.nlm.nih.gov/pubmed/23887802
Keywords:
AREDS2; cataract; lens opacity
Abstract:
{PURPOSE: We described the system for grading lens opacities using stereoscopic digital fundus reflex photographs in the Age-Related Eye Disease Study 2 (AREDS2) and compared reproducibility with the AREDS lens grading system, which used retroillumination film images. METHODS: Stereoscopic fundus reflex photographs were acquired in a standardized fashion at baseline and annually. Images were enhanced and evaluated in the red channel at a central reading center. Percentage involvement of cortical and posterior subcapsular (PSC) lens opacities within the central 5 mm diameter zone of a modified AREDS lens grid was estimated. Reproducibility was assessed for contemporaneous variability (ongoing, monthly regrade on 5% of submissions
