Multimodal Imaging in Type 2 Idiopathic Macular Telangiectasia
04/2015
Journal Article
Authors:
Sallo, F.B.;
Leung, I.;
Clemons, T.E.;
Peto, T.;
Bird, A.C.;
Pauleikhoff, D.
Secondary:
Retina
Volume:
35
Pagination:
742-749
URL:
http://www.ncbi.nlm.nih.gov/pubmed/25412037
Abstract:
{BACKGROUND:: Macular telangiectasia Type 2 is a bilateral, progressive potentially blinding retinal disease characterized by both vascular and neurodegenerative signs that have been documented using different imaging techniques. The correlation between macular telangiectasia Type 2 signs from various imaging modalities is unknown. Our aim was to investigate the relationship of various macular telangiectasia Type 2 signs using fundus fluorescein angiography, optical coherence tomography and dual-wavelength autofluorescence images. METHODS:: Participants were selected from the macular telangiectasia Type 2 Natural History Observation Study, based on a confirmed diagnosis and the availability of images. Signs in fundus fluorescein angiography, dual-wavelength autofluorescence, and optical coherence tomography images were graded according to standardized categories, and agreement among the multimodel imaging was assessed statistically. RESULTS:: One hundred and ninety-one eyes of 96 patients were examined. Significant correlations were found between early and late fundus fluorescein angiography (rho = 0.82, P < 0.0001), luteal pigment loss and early/late fundus fluorescein angiography signs (rho = 0.52, P < 0.0001 and rho = 0.62, P < 0.0001, respectively), inner and outer segment break length and pigment loss (Class 1 vs. 2/3, P < 0.0001; Class 2 vs. 3
