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Safety and immunogenicity of a single dose of Tdap compared to Td in pregnant women in Mali and 3 its effect on infant immune responses: a single-centre, randomised, double-blind, active-controlled phase 2 study

03/2024

Journal Article

Authors:
Fadima Cheick Haidara,; Milagritos D. Tapia,; Fatoumata Diallo,; Susana Portillo,; Margaret Williams,; Awa Traoré,; Elizabeth Rotrosen,; Elizabeth Hensel,; Mat Makowski,; Semhal Selamawi,; Jonathan A. Powell,; Karen L. Kotloff,; Marcela F. Pasetti,; Samba O. Sow; Kathleen M. Neuzilb

Volume:
71

Journal:
eClinicalMedicine

URL:
https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(24)00135-4/fulltext#secsectitle0040

DOI:
https://doi.org/10.1016/j.eclinm.2024.102556

Keywords:
Maternal pertussis immunisation Blunted immune response Malignant Conditions (Myeloid Disease)

Abstract:
While maternal pertussis vaccination is a strategy to reduce infant morbidity, safety and immunogenicity data are limited in sub-Saharan Africa. We aimed to evaluate the safety of a single dose of tetanus, diphtheria and acellular pertussis vaccine (Tdap) vaccine compared to tetanus and diphtheria vaccine (Td) vaccine in pregnant women in Bamako, Mali and to assess the pertussis toxin (PT) antibody response at birth.

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